Nevertheless, the time that takes in being developed this stage is quite long and depends on many factors. The virus begins to happen from neurons to others through the sinpticos contacts, which causes that the immune system is incapable to detect them. From the brain it can travel, through the nerves, to any part of the body, causing a systemic infection Definitively, as the man mentions geosalud.com/enfermedades_infecciosas/rabia receives the virus of the rage through counted with the saliva of the ill animal. This means, that to be inoculated, it necessarily does not need to be bitten: it is enough that a edge, wound, deep scratch or burn in their skin make contact with enemy with the saliva of the rabid animal. But it does not matter which the penetration form: the virus always goes to the central nervous system.

The time of inoculation varies with the nature of the virus, the place of inoculation and the inoculated amount. – If the meeting point has been the head, the neck or the members superiors, the period of incubation will be brief, because the virus will reach the favorite region with greater rapidity (it arrives mainly at the central nervous system through the nervous trunks, propagating throughout the sensorial nerves). The cells welcome that it are destroyed. From the virus it emigrates there towards weaves, but mainly towards the salivary glands, of where it is excreted together with the saliva. The period of incubation is very variable. If the bite of the rabid animal were carried out through the clothes of the victim, only one small amount of contaminated saliva will arrive until the wound, and this can slow down the process of the affection.

It is possible to indicate that in 1881, Roux, Chamberland and Thuillier, members of the equipment of Louis Pasteur, they demonstrated that the central nervous system is the primary site of reproduction of the virus of the rage. These investigators transmitted the rage by means of the submenngea inoculation of rabbits. Pasteur administered to the vaccine for the first time the 6 of July of 1885 to the young person Joseph Meister, who had been bitten 14 times by a dog 60 hours before.